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HRID 84504作成日：2026年10月26日

[3-(Hydroxymethyl)phenyl]boronic acid → N-(2-chlorophenyl)-8-(3-(hydroxymethyl)phenyl)-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamide

https://huagongshe.com/reaction/84504

反応式

関与物質

役割名称HCID仕込み量
反応物[3-(Hydroxymethyl)phenyl]boronic acidHCID 2734662—
反応物8-bromo-N-(2-chlorophenyl)-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamideHCID 44242427—
生成物N-(2-chlorophenyl)-8-(3-(hydroxymethyl)phenyl)-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamideHCID 44241822—

反応手順

Following the procedure of Example 93, 8-bromo-N-(2-chlorophenyl)-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamide 150 and 3-hydroxymethylphenylboronic acid were reacted to give 201. MS: (ESI+) 476.16

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08846762B2
出典データセットuspto-grants-2014_09
ORD IDord-3fdf7e9c016e422db07da099f429eb8a
出典メモuspto-grants-2014_09