6-Chloropurine riboside → HCID 15611205、化合物

HRID 845123ノート

反応式

HRID 845123 の反応式
[C:1]1([C:7]2([CH2:13][NH2:14])[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:15]1[N:20]=[C:19](Cl)[C:18]2[N:22]=[CH:23][N:24]([C@@H:25]3[O:29][C@H:28]([CH2:30][OH:31])[C@@H:27]([OH:32])[C@H:26]3[OH:33])[C:17]=2[N:16]=1>>[C:1]1([C:7]2([CH2:13][NH:14][C:19]3[C:18]4[N:22]=[CH:23][N:24]([C:17]=4[N:16]=[CH:15][N:20]=3)[C@@H:25]3[O:29][C@H:28]([CH2:30][OH:31])[C@@H:27]([OH:32])[C@H:26]3[OH:33])[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

3

反応物 2

HCID 930036-Chloropurine ribosideHCID 205110Cyclohexanemethylamine, 1-phenyl-

生成物 1

HCID 15611205HCID 15611205、化合物収率 42.4%

実験手順

(1-Phenylcyclohexyl)methylamine (1.80 g, 8 mmol) as prepared below, and 6-chloropurine riboside (2.36 g, 8 mmol) are reacted as described in Example 1. The solvent is removed under reduced pressure, and the residue dissolved up in CHCl3 and washed with water and dried (MgSO4). The solvent is removed under reduced pressure and the residual white foam is purified on silica gel chromatography eluting with 10% MeOH in CH2Cl2 to give N6-((1-phenylcyclohexyl)methyl)adenosine (1.49 g, 42%) as a white glass m.p. 87°-9° C. Found: C, 62.22; H, 6.96; N, 15.70%. C23H29N5O4 calculated requires: C, 62.87; H, 6.61; N, 15.95%.

後処理

  1. customare reacted
  2. customThe solvent is removed under reduced pressure
  3. dissolutionthe residue dissolved up in CHCl3
  4. washwashed with water
  5. dry with materialdried (MgSO4)
  6. customThe solvent is removed under reduced pressure
  7. customthe residual white foam is purified on silica gel chromatography
  8. washeluting with 10% MeOH in CH2Cl2

出典と根拠

ORDレコード
ord-652a1ccacd814f8b86b6ed43fbedd285
出典データセット
uspto-grants-1988_07
特許番号
US04755594

反応ノート

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