1-Phenylcyclohexanecarbonitrile → (1-Phenylcyclohexyl)methanamine

HRID 845124ノート

反応式

HRID 845124 の反応式
[C:1]1([C:7]2([C:13]#[N:14])[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>CO.[Ni]>[C:1]1([C:7]2([CH2:13][NH2:14])[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

4

反応物 1

HCID 751481-Phenylcyclohexanecarbonitrile

生成物 1

HCID 205110(1-Phenylcyclohexyl)methanamine

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 887Methanol溶媒

実験手順

1-Phenylcyclohexane carbonitrile is reduced with H2 in methanol containing 16% ammonia with a Raney nickel catalyst. The catalyst is filtered off and (1-phenylcyclohexyl)methylamine is precipitated as its hydrochloride salt m.p. 230°-33° C., by treatment with methanolic HCl and isopropyl ether.

後処理

  1. filtrationThe catalyst is filtered off
  2. custom(1-phenylcyclohexyl)methylamine is precipitated as its hydrochloride salt m.p. 230°-33° C., by treatment with methanolic HCl and isopropyl ether

出典と根拠

ORDレコード
ord-22684cdcfb2a427dbdacba43284a77b9
出典データセット
uspto-grants-1988_07
特許番号
US04755594

反応ノート

読み込み中…