化工社化工社 化学情報印刷レポート · 研究参考用
Bromine → 4-Bromo-3,4-dihydro-1-benzoxepin-5(2H)-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Bromine | HCID 24408 | — |
| 反応物 | 2,3,4,5-Tetrahydro-1-benzoxepin-5-one | HCID 315575 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 4-Bromo-3,4-dihydro-1-benzoxepin-5(2H)-one | HCID 13863234 | — |
反応手順
To a solution of 3,4-dihydro-2H-benzo[b]oxepin-5-one (3.10 g, 12.8 mmol) in diethyl ether at 0° C., bromine (625 μl, 12.2 mmol) was added and stirred for 2.5 hours, gradually raising the temperature to room temperature. Purification on silica and triturating using diethyl ether and hexanes gave 4-bromo-3,4-dihydro-2H-benzo[b]oxepin-5-one.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08846762B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-2c48424fc66e4bfbbf7a255b7d0ce46f |
| 出典メモ | uspto-grants-2014_09 |