Butyl 3-furyl(hydroxy)acetate → Butyl 2-(fur-3-yl)-2-oxo-acetate

HRID 845253ノート

反応式

HRID 845253 の反応式
[O:1]1[CH:5]=[CH:4][C:3]([CH:6]([OH:14])[C:7]([O:9][CH2:10][CH2:11][CH2:12][CH3:13])=[O:8])=[CH:2]1.C([O-])(=O)C.C([O-])(=O)C.C([O-])(=O)C.C([O-])(=O)C.[Pb+4]>C1C=CC=CC=1>[O:1]1[CH:5]=[CH:4][C:3]([C:6](=[O:14])[C:7]([O:9][CH2:10][CH2:11][CH2:12][CH3:13])=[O:8])=[CH:2]1

参加物

4

反応物 2

HCID 12335665Butyl 3-furyl(hydroxy)acetateHCID 178418268HCID 178418268、化合物

生成物 1

HCID 13986137Butyl 2-(fur-3-yl)-2-oxo-acetate収率 83.4%

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

A mixture of 39.6 g of butyl fur-3-yl-glycolate and 8.6 g of lead tetraacetate in 400 ml of absolute benzene is refluxed for 8 hours. After cooling to room temperature, the salts are filtered off and washed with benzene, and the combined benzene phases are shaken with a 10% strength sodium bicarbonate solution and a saturated sodium chloride solution. After drying over sodium sulphate, filtering off and concentrating, the oily residue is distilled in vacuo. 32.7 g (83%) of an oil, boiling point 80° C. (0.3 Torr), nD20 =1.477, are obtained.

後処理

  1. temperatureis refluxed for 8 hours
  2. filtrationthe salts are filtered off
  3. washwashed with benzene
  4. dry with materialAfter drying over sodium sulphate
  5. filtrationfiltering off
  6. concentrationconcentrating
  7. distillationthe oily residue is distilled in vacuo

出典と根拠

ORDレコード
ord-56a45a5dfd974825b9f1604ecb08b06a
出典データセット
uspto-grants-1988_07
特許番号
US04757085

反応ノート

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