Methyl Anthranilate → Methyl 2-(1H-pyrrol-1-yl)benzoate

HRID 845380

反応式

HRID 845380 の反応式
[C:1]([O:10][CH3:11])(=[O:9])[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[NH2:4].CO[CH:14]1[CH2:18][CH2:17][CH:16](OC)O1>C(O)(=O)C>[N:4]1([C:3]2[CH:5]=[CH:6][CH:7]=[CH:8][C:2]=2[C:1]([O:10][CH3:11])=[O:9])[CH:14]=[CH:18][CH:17]=[CH:16]1

参加物

4

反応物 2

HCID 8635Methyl AnthranilateHCID 790982,5-Dimethoxytetrahydrofuran

生成物 1

HCID 2776733Methyl 2-(1H-pyrrol-1-yl)benzoate

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A mixture of 500 g of methyl anthranilate and 438 g of 2,5-dimethoxytetrahydrofuran in 670 ml of glacial acetic acid is heated at reflux temperature for 11/2 hours. The acetic acid is then evaporated under reduced pressure and the residue is distilled to yield methyl 2-(1H-pyrrol-1-yl)-benzoate, b.p. 109°/0.1 mm Hg.

後処理

  1. temperatureis heated
  2. temperatureat reflux temperature for 11/2 hours
  3. customThe acetic acid is then evaporated under reduced pressure
  4. distillationthe residue is distilled

出典と根拠

ORDレコード
ord-0bfb77e6bc12409ebf3689e5c4715367
出典データセット
uspto-grants-1988_07
特許番号
US04758559

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