Hydrochloric Acid → SC 44942-A

HRID 845384ノート

反応式

HRID 845384 の反応式
[CH3:1][C:2]1([CH3:27])[CH2:26][N:6]2[C:7]3[C:12]([N+:13]([O-:21])=[C:14]([C:15]4[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=4)[C:5]2=[N:4][CH2:3]1)=[CH:11][C:10]([C:22]([F:25])([F:24])[F:23])=[CH:9][CH:8]=3.[ClH:28]>C(O)C>[ClH:28].[CH3:1][C:2]1([CH3:27])[CH2:26][N:6]2[C:7]3[C:12]([N+:13]([O-:21])=[C:14]([C:15]4[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=4)[C:5]2=[N:4][CH2:3]1)=[CH:11][C:10]([C:22]([F:24])([F:25])[F:23])=[CH:9][CH:8]=3

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 3082690HCID 3082690、化合物

生成物 1

HCID 3082689SC 44942-A

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

2,3-Dihydro-2,2-dimethyl-5-phenyl-8-trifluoromethyl-1H-pyrimido[1,2-a]quinoxaline 6-oxide (70 g) was suspended in ethanol (500 ml) and cooled in an ice-bath. Gaseous hydrogen chloride was passed through the suspension until all solid had dissolved. The solvent was then removed in vacuo and the resulting solid recrystallized from hot ethyl acetate to yield 57.87 g of 2,3-dihydro-2,2-dimethyl-5-phenyl-8-trifluoromethyl-1H-pyrimido[ 1,2-a]quinoxaline 6-oxide hydrochloride as a bright yellow crystalline solid, m.p. 234° C., (Found: C, 58.43, H, 4.68, N, 10.15%; C20H19ClF3N3O requires C, 58.61, H, 4.67, N, 10.25%) and represented by the structural formula: ##STR15##

後処理

  1. temperaturecooled in an ice-bath
  2. dissolutionhad dissolved
  3. customThe solvent was then removed in vacuo
  4. customthe resulting solid recrystallized from hot ethyl acetate

出典と根拠

ORDレコード
ord-7a7e72a543f34529aa19e7e326bed1e5
出典データセット
uspto-grants-1988_07
特許番号
US04758565

反応ノート

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