Ethanol → 2-Acetylpyridine 4-(2-morpholinoethyl)thiosemicarbazone

HRID 845395

反応式

HRID 845395 の反応式
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][NH:9][C:10](=[S:13])[NH:11][NH2:12])[CH2:3][CH2:2]1.[C:14]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=1)(=O)[CH3:15].C(O)C>C(O)(=O)C>[O:1]1[CH2:2][CH2:3][N:4]([CH2:7][CH2:8][NH:9][C:10](=[S:13])[NH:11][N:12]=[C:14]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=2)[CH3:15])[CH2:5][CH2:6]1

参加物

5

反応物 3

HCID 702EthanolHCID 142862-AcetylpyridineHCID 7362093-Amino-1-(2-(morpholin-4-yl)ethyl)thiourea

生成物 1

HCID 544028592-Acetylpyridine 4-(2-morpholinoethyl)thiosemicarbazone

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A mixture of 6.00 g (0.0294 mole) of 4-(2-morpholinoethyl)thiosemicarbazide, 3.91 g (0.0323 mole) of 2-acetylpyridine, 20 mL of 95% ethanol, and 0.4 mL of glacial acetic acid was heated under reflux for 1.25 hours. The mixture then stood overnight at room temperature. Colourless crystals were collected and recrystallised from 40 mL of 95% ethanol; yield 7.81 g (86%) of pale yellow crystals of 2-acetylpryridine 4-(2-morpholinoethyl)thiosemicarbazone, mp 167.5°-169° C.

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 1.25 hours
  3. customColourless crystals were collected
  4. customrecrystallised from 40 mL of 95% ethanol

出典と根拠

ORDレコード
ord-1146570031294c70b5319c308ba10868
出典データセット
uspto-grants-1988_07
特許番号
US04758572

関連ノート

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