Neopentyl alcohol → HCID 545965、化合物
反応式
[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7](Cl)=[O:8].[CH3:10][C:11]([CH3:15])([CH3:14])[CH2:12][OH:13]>C1C=CC=CC=1>[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([O:13][CH2:12][C:11]([CH3:15])([CH3:14])[CH3:10])=[O:8]参加物
4
実験手順
A solution of 6-bromohexanoyl chloride (10.0 g, 0.047 mol) and 2,2-dimethylpropanol (4.96 g, 0.056 mol) in benzene (100 ml) was heated under reflux for 2 hours. The solvent was evaporated off under reduced pressure and the residue was dissolved in dichloromethane (200 ml), washed with aqueous sodium hydroxide (2M, 50 ml), water (50 ml) and dried (Na2SO4). The solvent was evaporated off under reduced pressure to give the crude product which was further purified by column chromatography (alumina, dichloromethane) to give neopentyl 6-bromohexanoate as a colourless oil.
後処理
- temperatureunder reflux for 2 hours
- customThe solvent was evaporated off under reduced pressure
- dissolutionthe residue was dissolved in dichloromethane (200 ml)
- washwashed with aqueous sodium hydroxide (2M, 50 ml), water (50 ml)
- dry with materialdried (Na2SO4)
- customThe solvent was evaporated off under reduced pressure
- customto give the crude product which
- customwas further purified by column chromatography (alumina, dichloromethane)
出典と根拠
- ORDレコード
- ord-2429bf2308a5401b926a19c8bd73de14
- 出典データセット
- uspto-grants-1988_07
- 特許番号
- US04758573
反応ノート
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