6-[2-(2-aminoethyl)benzimidazol-5-yl]-4,5-dihydro-5-methyl-3(2H)-pyridazinone → 6-[2-[2-[3-(4-(2-Isobutoxy-ethyl)phenoxy)-2-hydroxypropylamino]ethyl]benzimidazol-5-yl]-4,5-dihydro-5-methyl-3(2H)-pyridazinone

HRID 846137ノート

反応式

HRID 846137 の反応式
[CH2:1]([O:5][CH2:6][CH2:7][C:8]1[CH:18]=[CH:17][C:11]([O:12][CH2:13][CH:14]2[O:16][CH2:15]2)=[CH:10][CH:9]=1)[CH:2]([CH3:4])[CH3:3].[NH2:19][CH2:20][CH2:21][C:22]1[NH:23][C:24]2[CH:30]=[C:29]([C:31]3[CH:32]([CH3:38])[CH2:33][C:34](=[O:37])[NH:35][N:36]=3)[CH:28]=[CH:27][C:25]=2[N:26]=1>>[CH2:1]([O:5][CH2:6][CH2:7][C:8]1[CH:18]=[CH:17][C:11]([O:12][CH2:13][CH:14]([OH:16])[CH2:15][NH:19][CH2:20][CH2:21][C:22]2[NH:23][C:24]3[CH:30]=[C:29]([C:31]4[CH:32]([CH3:38])[CH2:33][C:34](=[O:37])[NH:35][N:36]=4)[CH:28]=[CH:27][C:25]=3[N:26]=2)=[CH:10][CH:9]=1)[CH:2]([CH3:4])[CH3:3]

参加物

3

反応物 2

HCID 144040656-[2-(2-aminoethyl)benzimidazol-5-yl]-4,5-dihydro-5-methyl-3(2H)-pyridazinoneHCID 151078061-[4-(2-Isobutoxyethyl)phenoxy]-2,3-epoxypropane

生成物 1

HCID 151078466-[2-[2-[3-(4-(2-Isobutoxy-ethyl)phenoxy)-2-hydroxypropylamino]ethyl]benzimidazol-5-yl]-4,5-dihydro-5-methyl-3(2H)-pyridazinone

実験手順

Prepared analogously to Example 1 from 1-[4-(2-isobutoxy-ethyl)-phenoxy]-2,3-epoxypropane and 6-[2-(2-aminoethyl)benzimidazol-5-yl]-4,5-dihydro-5-methyl-3(2H)-pyridazinone.

出典と根拠

ORDレコード
ord-04b7878d2e4443b78311a2fc0351c6ef
出典データセット
uspto-grants-1992_08
特許番号
US05135932

反応ノート

読み込み中…