Malonic Acid → 3-Amino-3-(4-fluorophenyl)propanoic acid

HRID 846199ノート

反応式

HRID 846199 の反応式
[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[CH:4][CH:3]=1.[C:10]([OH:16])(=[O:15])[CH2:11]C(O)=O.C([O-])(=O)C.[NH4+:21]>C(O)C>[NH2:21][CH:6]([C:5]1[CH:8]=[CH:9][C:2]([F:1])=[CH:3][CH:4]=1)[CH2:11][C:10]([OH:16])=[O:15]

参加物

5

反応物 3

HCID 867Malonic AcidHCID 680234-FluorobenzaldehydeHCID 517165Ammonium Acetate

生成物 1

HCID 5798853-Amino-3-(4-fluorophenyl)propanoic acid収率 23.6%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 24.8 g (0.2 mol) of 4-fluorobenzaldehyde, 20.8 g (0.2 mol) of malonic acid, 30.8 g (0.4 mol) of ammonium acetate and 550 ml of ethanol was refluxed for approximately seven hours. The mixture was cooled and the precipitated solid was collected by vacuum filtration. The solid was recrystallized from 500 ml of water to provide 8.66 g of 3-amino-3-(4-fluorophenyl)propionic acid. mp=225° C. dec.

後処理

  1. temperatureThe mixture was cooled
  2. filtrationthe precipitated solid was collected by vacuum filtration
  3. customThe solid was recrystallized from 500 ml of water

出典と根拠

ORDレコード
ord-a69e73985bce4a68ba141535975245a6
出典データセット
uspto-grants-1992_08
特許番号
US05135947

反応ノート

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