Sulfuric Acid → HCID 14698595、化合物

HRID 846208ノート

反応式

HRID 846208 の反応式
[C:1]([C:3]([C:6]1[CH:11]=[CH:10][C:9]([NH:12][C:13](=[O:22])[C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=2)=[CH:8][CH:7]=1)([CH3:5])[CH3:4])#[N:2].S(=O)(=O)(O)[OH:24]>>[NH2:2][C:1]([C:3]([C:6]1[CH:11]=[CH:10][C:9]([NH:12][C:13](=[O:22])[C:14]2[CH:15]=[CH:16][C:17]([O:20][CH3:21])=[CH:18][CH:19]=2)=[CH:8][CH:7]=1)([CH3:5])[CH3:4])=[O:24]

参加物

3

反応物 2

HCID 1118Sulfuric AcidHCID 14698596HCID 14698596、化合物

生成物 1

HCID 14698595HCID 14698595、化合物

実験手順

5 g. N-[4-(1-Cyano-1-methylethyl)-phenyl]-4-methoxybenzamide (Example 27) are stirred for 20 hours at ambient temperature in 100 ml. concentrated sulphuric acid, poured on to ice, the precipitate is filtered off with suction, dissolved in hot glacial acetic acid, water added thereto until the commencement of turbidity and then left to cool. There are obtained 2.2 g. (42% of theory) of the title compound in the form of colourless crystals; m.p. 234°-235° C.

後処理

  1. filtrationthe precipitate is filtered off with suction
  2. dissolutiondissolved in hot glacial acetic acid
  3. additionwater added
  4. waituntil the commencement of turbidity and then left
  5. temperatureto cool
  6. customThere are obtained 2.2 g

出典と根拠

ORDレコード
ord-f5e27edd7b3046fc8b07123cd5c28b19
出典データセット
uspto-grants-1992_08
特許番号
US05135949

反応ノート

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