Hydrochloric Acid → 1-[4-(Methylthio)phenyl]-1-propanone

HRID 846234ノート

反応式

HRID 846234 の反応式
[C:1]1([S:7][CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:9](Cl)(=[O:12])[CH2:10][CH3:11].[Al+3].[Cl-].[Cl-].[Cl-].Cl>ClC(Cl)C.O>[CH3:8][S:7][C:1]1[CH:6]=[CH:5][C:4]([C:9](=[O:12])[CH2:10][CH3:11])=[CH:3][CH:2]=1

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 7520ThioanisoleHCID 62324Propionyl chlorideHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 8211711-[4-(Methylthio)phenyl]-1-propanone

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 63651,1-Dichloroethane溶媒

実験手順

To a mixture of thioanisole (5.0 g) and propionyl chloride (3.9 ml) at 0° C. in dichloroethane (80 ml) was added AlCl3 (6.4 g) in portions. The mixture was stirred 12 hours at ambient temperature, poured into water (200 ml) and conc. HCl (2 ml), then extracted with CH2Cl2. The extract was reduced to dryness to provide the title compound mp 60°-61° C. after purification by chromatography on silica gel.

後処理

  1. extractionextracted with CH2Cl2

出典と根拠

ORDレコード
ord-78d5b8b098dc4f279cc9c0013bc77c03
出典データセット
uspto-grants-1992_08
特許番号
US05135940

反応ノート

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