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Piperidine → 4-[4-(Hexyloxy)phenyl]-3-(4-methoxyphenyl)-2-butanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Piperidine | HCID 8082 | — |
| 反応物 | 1-(p-Methoxyphenyl)-2-propanone | HCID 31231 | — |
| 反応物 | p-(Hexyloxy)benzaldehyde | HCID 79816 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 4-[4-(Hexyloxy)phenyl]-3-(4-methoxyphenyl)-2-butanone | HCID 19885147 | 46% |
反応手順
49.2 g of 3-(4-methoxyphenyl)-2-propanone and 61.8 g of 4-hexyloxybenzaldehyde were added to 100 ml of toluene containing 4 ml of piperidine. The resultant mixture was heated at reflux temperature overnight after which the solvent was removed in vacuo to afford the desired subtitled intermediate (46% yield), b.p. 230°-235° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05135955 |
| 出典データセット | uspto-grants-1992_08 |
| ORD ID | ord-19e7f61cde12489b985d8cc75dfc7d32 |
| 出典メモ | uspto-grants-1992_08 |