Hydrochloric Acid → isopropyl (2RS,3S)-3-amino-2-hydroxy-5-methylhexanoate hydrochloride
反応式
[NH2:1][CH:2]([CH2:8][CH:9]([CH3:11])[CH3:10])[CH:3]([OH:7])[C:4]([OH:6])=[O:5].[ClH:12].[C:13]1(C)[CH:18]=CC=C[CH:14]=1>C(O)(C)C>[ClH:12].[NH2:1][C@@H:2]([CH2:8][CH:9]([CH3:11])[CH3:10])[CH:3]([OH:7])[C:4]([O:6][CH:13]([CH3:18])[CH3:14])=[O:5]参加物
5
実験手順
3-Amino-2-hydroxy-5-methylhexanoic acid (Example A), 26.5 g (0.164 mol), is dissolved in isopropyl alcohol, treated with hydrochloric acid (anhydrous) for five minutes, treated with toluene (250 ml) and 3A molecular seives and warmed to reflux for 15 minutes. The solution is cooled to room temperature, filtered, and the solvents evaporated in vacuo to give the title compound as an extremely hygroscopic foam, 40 g. The foam is used without further purification.
後処理
- temperaturewarmed
- temperatureto reflux for 15 minutes
- filtrationfiltered
- customthe solvents evaporated in vacuo
出典と根拠
- ORDレコード
- ord-387fd8d0b14c4ccfb6451d15c30468f0
- 出典データセット
- uspto-grants-1992_08
- 特許番号
- US05135914
反応ノート
読み込み中…