beta-[[(1,1-Dimethylethoxy)carbonyl]amino]-alpha-hydroxycyclohexanebutanoic acid, 1-methylethyl ester → beta-Amino-alpha-hydroxycyclohexanebutanoic acid, 1-methylethyl ester

HRID 846466ノート

反応式

HRID 846466 の反応式
CC(C)(OC([NH:7][CH:8]([CH2:17][CH:18]1[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1)[CH:9]([OH:16])[C:10]([O:12][CH:13]([CH3:15])[CH3:14])=[O:11])=O)C>C(Cl)Cl>[NH2:7][CH:8]([CH2:17][CH:18]1[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]1)[CH:9]([OH:16])[C:10]([O:12][CH:13]([CH3:14])[CH3:15])=[O:11]

参加物

3

反応物 1

HCID 15674228beta-[[(1,1-Dimethylethoxy)carbonyl]amino]-alpha-hydroxycyclohexanebutanoic acid, 1-methylethyl ester

生成物 1

HCID 3256856beta-Amino-alpha-hydroxycyclohexanebutanoic acid, 1-methylethyl ester収率 73%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
0 °C

実験手順

β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxycyclohexanebutanoic acid, 1-methylethyl ester (mixture of [R-(R*,S*)] and [S-(R*,R*)]isomers) (Example F), 3.4 g (10 mmol), is dissolved in methylene chloride, cooled to 0° C. and hydrochloric acid gas is bubbled in for five minutes every 15 minutes for two hours. The solution is diluted with ethyl acetate (50 ml) washed with saturated sodium bicarbonate solution (100 ml) and then with saturated brine solution (100 ml). The organics are separated, dried over magnesium sulfate and evaporated to dryness in vacuo to give 1.75 g (73%) of the title compound as an oil.

後処理

  1. customhydrochloric acid gas is bubbled in for five minutes every 15 minutes for two hours
  2. additionThe solution is diluted with ethyl acetate (50 ml)
  3. washwashed with saturated sodium bicarbonate solution (100 ml)
  4. customThe organics are separated
  5. dry with materialdried over magnesium sulfate
  6. customevaporated to dryness in vacuo

出典と根拠

ORDレコード
ord-c0c0271fc7a84572b584da7e38f4868b
出典データセット
uspto-grants-1992_08
特許番号
US05135914

反応ノート

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