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p-Tolyl isothiocyanate → 3-(4-Methylphenyl)-5-[[(phenylmethyl)thio]methyl]-2-thioxo-4-imidazolidinone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | p-Tolyl isothiocyanate | HCID 12149 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | S-benzyl-L-cysteine | HCID 193613 | — |
| 生成物 | 3-(4-Methylphenyl)-5-[[(phenylmethyl)thio]methyl]-2-thioxo-4-imidazolidinone | HCID 15295744 | 111.7% |
反応手順
When 10 g of S-benzylcysteine (0.0473 mole), 1.89 g of sodium hydroxide (0.0473 mole) and 7.05 g of p-tolylisothiocyanate (0.0473 mole) was reacted according to the procedure outlined in the preparation of Example 2, 18.1 g of the crude thiourea was obtained and 14.3 g of pure title compound was obtained: RF on silica gel=approximately 0.33 [ethyl acetate-hexane (3:7)].
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05137904 |
| 出典データセット | uspto-grants-1992_08 |
| ORD ID | ord-1647b70e3fef437ebfcc988ead56c1b0 |
| 出典メモ | uspto-grants-1992_08 |