Propargyl bromide → Methyl Isocyanate

HRID 846645ノート

反応式

HRID 846645 の反応式
[CH3:1][N:2]1[CH:6]=[CH:5][N:4]([CH2:7][C:8]#[CH:9])[C:3]1=[O:10].C(OC(OCC)CN)C.C(Br)C#C>>[CH2:7]([N:4]1[CH:5]=[CH:6][NH:2][C:3]1=[O:10])[C:8]#[CH:9].[CH3:1][N:2]=[C:3]=[O:10]

参加物

5

反応物 3

HCID 7842Propargyl bromideHCID 695242,2-DiethoxyethylamineHCID 150655051,3-Dihydro-1-methyl-3-(2-propyn-1-yl)-2H-imidazol-2-one

生成物 2

HCID 12228Methyl IsocyanateHCID 197532861,3-dihydro-1-(2-propynyl)-2H-imidazol-2-one

実験手順

The 1,3-dihydro-1-(2-propynyl)-2H-imidazol-2-one intermediates were prepared as outlined in Scheme 2 for the synthesis of 1,3-dihydro-1-methyl-3-(2-propynyl)-2H-imidazol-2-one (X). Aminoacetaldehyde diethyl acetal was reacted with propargylbromide to give a mixture of the tertiary and secondary amines VII and VIII which were separated by chromatography on silica gel. Treatment of VIII with methyl isocyanate gave IX and this was heated in aqueous oxalic acid to give 1-methyl-3-(2-propynyl)-2H-imidazol-2-one (X).

後処理

  1. customto give
  2. customwere separated by chromatography on silica gel

出典と根拠

ORDレコード
ord-4309b6199d1c4e1ebeeeaae0623c05f8
出典データセット
uspto-grants-1992_08
特許番号
US05137905

反応ノート

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