Cyanogen Bromide → 1-(4-bromo-2-butynyl)-1,3-dihydro-3-methyl-2H-imidazol-2-one
反応式
N#[C:2][Br:3].C(N(CC)C[C:8]#[C:9][CH2:10][N:11]1[CH:15]=[CH:14][N:13]([CH3:16])[C:12]1=[O:17])C>O1CCOCC1>[Br:3][CH2:2][C:8]#[C:9][CH2:10][N:11]1[CH:15]=[CH:14][N:13]([CH3:16])[C:12]1=[O:17]参加物
4
実験手順
Cyanogen bromide (6.0 g, 0.057 mol) was added to a stirred solution of 1-[4-(diethylamino)-2-butynyl]-1,3-dihydro-3-methyl-2H-imidazol-2-one in dioxane (130 mL). After evaporation of the dioxane, the residual oil was chromatographed on silica gel using chloroform:1% methanol as the eluant to give 10.8 g of 1-(4-bromo-2-butynyl)-1,3-dihydro-3-methyl-2H-imidazol-2-one as an oil.
後処理
- customAfter evaporation of the dioxane
- customthe residual oil was chromatographed on silica gel
出典と根拠
- ORDレコード
- ord-40c141d7961d465bb4ad8f3f47e88ae7
- 出典データセット
- uspto-grants-1992_08
- 特許番号
- US05137905
反応ノート
読み込み中…