関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Formaldehyde | HCID 712 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | N-tert-butylhydroxylamine hydrochloride | HCID 2777896 | — |
| 反応物 | Dibenzylphosphite | HCID 21904359 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | Dibenzyl P-(N-tert-Butyl-N-hydroxyaminomethyl)phosphonate | HCID 19883778 | 64% |
反応手順
Using the procedure of Example 1, the above-named compound is prepared from 5.0 g (40 mmol) of N-tert-butylhydroxylamine hydrochloride, 2.4 g (80 mmol) of paraformaldehyde, 9.0 g (41 mmol) of dibenzyl phosphite, 3.0 g (40 mmol) of sodium bicarbonate and 200 ml of tetrahydrofuran (THF) by heating at 55° C. for 14 hours. The residue is purified by recrystallization from a mixture of methylene chloride and hexane to give 9.2 g (64% yield) of a white solid melting at 106°-107° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US05137951 |
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| 出典データセット | uspto-grants-1992_08 |
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| ORD ID | ord-8b4937138b114f51953c304be4aae8cb |
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| 出典メモ | uspto-grants-1992_08 |
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