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Methanol → Methyl 2-(4,6-dimethoxypyrimidin-2-yl)oxybut-2-enoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Methyl 2-hydroxybut-3-enoate | HCID 545123 | — |
| 反応物 | 4,6-Dimethoxy-2-(methylsulfonyl)pyrimidine | HCID 838363 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 溶媒 | Methyl Ethyl Ketone | HCID 6569 | — |
| 生成物 | Methyl 2-(4,6-dimethoxypyrimidin-2-yl)oxybut-2-enoate | HCID 53952661 | 78.1% |
反応手順
A mixture of methyl 2-hydroxybut-3-enoate (0.80g, 6.9mmol), 4,6-dimethoxy-2-methanesulphonylpyrimidine (1.50g, 6.9mmol) and potassium carbonate (1.04g, 7.6mmol) in methyl ethyl ketone (100ml) was refluxed for 12 hours. The reaction mixture was filtered and the filtrate evaporated in vacuo. Flash column chromatography (silica, 1.5% methanol in chloroform) of the residue gave the title compound (1.37g, 78% yield by weight).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05139563 |
| 出典データセット | uspto-grants-1992_08 |
| ORD ID | ord-926200faf6b44bfaa25326ff0c79f915 |
| 出典メモ | uspto-grants-1992_08 |