Ethylenediamine → trans-4-(2-Aminoethylamino)-6-cyano-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-3-ol

HRID 847167ノート

反応式

HRID 847167 の反応式
[C:1]([C:3]1[CH:4]=[CH:5][C:6]2[O:11][C:10]([CH3:13])([CH3:12])[CH:9]3[O:14][CH:8]3[C:7]=2[CH:15]=1)#[N:2].[CH2:16]([NH2:19])[CH2:17][NH2:18]>C(O)C>[NH2:18][CH2:17][CH2:16][NH:19][C@@H:8]1[C:7]2[CH:15]=[C:3]([C:1]#[N:2])[CH:4]=[CH:5][C:6]=2[O:11][C:10]([CH3:13])([CH3:12])[C@H:9]1[OH:14]

参加物

4

反応物 2

HCID 3301EthylenediamineHCID 108673602,2-Dimethyl-3,4-epoxy-6-cyanochroman

生成物 1

HCID 15680853trans-4-(2-Aminoethylamino)-6-cyano-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-3-ol収率 111.5%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a suspension of 6-cyano-3,4-epoxy-3,4-dihydro-2,2-dimethyl-2H-benzopyran (1.2 g, 5.97 mmol) (prepared according to Evans et al., J. Med. Chem., 1983, 26, 1582 and J. Med. Chem., 1986, 29, 2194) in ethanol (7.0 mL), ethylenediamine (2.4 mL, 35.8 mmol) was added at room temperature and the reaction mixture was stirred at room temperature for 36 hours. The solvent was removed under reduced pressure and the residue was further dried by use of vacuum pump to yield the title A compound (1.74 g, >100%) as a colorless foam. This material was used for the next reaction without any purification.

後処理

  1. additionwas added at room temperature
  2. customThe solvent was removed under reduced pressure
  3. customthe residue was further dried by use of vacuum pump

出典と根拠

ORDレコード
ord-b5458a96f21d44c1ba60847dd71cb7fa
出典データセット
uspto-grants-1992_08
特許番号
US05140031

反応ノート

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