Benzonitrile, 4-isothiocyanato- → N-Cyano-N'-4-cyanophenylthiourea

HRID 847172

反応式

HRID 847172 の反応式
[N:1]#[C:2][NH2:3].[Na].[C:5]([C:7]1[CH:12]=[CH:11][C:10]([N:13]=[C:14]=[S:15])=[CH:9][CH:8]=1)#[N:6]>C(O)C>[C:2]([NH:3][C:14]([NH:13][C:10]1[CH:11]=[CH:12][C:7]([C:5]#[N:6])=[CH:8][CH:9]=1)=[S:15])#[N:1]

参加物

4

反応物 2

HCID 17626Benzonitrile, 4-isothiocyanato-HCID 57375518Cyanamidnatrium

生成物 1

HCID 14569040N-Cyano-N'-4-cyanophenylthiourea収率 73.6%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

The suspension of monosodium cyanamide (4.3 g, 67.2 mmol) in absolute ethanol (170 mL) was slowly treated with 4-cyanophenylisothiocyanate (10.75 g, 67.2 mmol). The reaction was allowed to stir at room temperature for 1 hour and then heated at 75° C. for 4 hours. The reaction was cooled to room temperature and the colorless solid was filtered and washed with ethanol to give the title A compound (10.0 g), m.p. >250° C.

後処理

  1. temperatureheated at 75° C. for 4 hours
  2. temperatureThe reaction was cooled to room temperature
  3. filtrationthe colorless solid was filtered
  4. washwashed with ethanol

出典と根拠

ORDレコード
ord-0cc632371a614192a2f5dfd4c16970fe
出典データセット
uspto-grants-1992_08
特許番号
US05140031

関連ノート

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