1-(Trimethylsilyl)pyrrolidin-2-one → 1-(4'-Bromophenoxycarbonyl)-2-pyrrolidinone

HRID 847222

反応式

HRID 847222 の反応式
Cl[C:2]([O:4][C:5]1[CH:10]=[CH:9][C:8]([Br:11])=[CH:7][CH:6]=1)=[O:3].C[Si](C)(C)[N:14]1[CH2:18][CH2:17][CH2:16][C:15]1=[O:19]>C1C=CC=CC=1>[Br:11][C:8]1[CH:9]=[CH:10][C:5]([O:4][C:2]([N:14]2[CH2:18][CH2:17][CH2:16][C:15]2=[O:19])=[O:3])=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 844611-(Trimethylsilyl)pyrrolidin-2-oneHCID 52377364-Bromophenyl chloroformate

生成物 1

HCID 197515271-(4'-Bromophenoxycarbonyl)-2-pyrrolidinone収率 53%

試薬・触媒・溶媒 1

HCID 241Benzene溶媒2 回

実験手順

To a solution of 4-bromophenyl chloroformate (4.19 g, 20.0 mmol) in anhydrous benzene (20 ml) was added a solution of 1-trimethylsilyl-2-pyrrolidinone (3.46 g, 22.0 mmol) in anhydrous benzene (10 ml). The mixture was stirred at room temperature for 30 min. The reaction mixture was evaporated under reduced pressure to dryness to give a solid material. Recrystallization from 2-propanol afforded 3.00 g of colorless prisms. Yield 53%

後処理

  1. customThe reaction mixture was evaporated under reduced pressure to dryness
  2. customto give a solid material
  3. customRecrystallization from 2-propanol

出典と根拠

ORDレコード
ord-84b29e23496146fe8a04e42fd72c8965
出典データセット
uspto-grants-1992_08
特許番号
US05140041

関連ノート

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