Hydrochloric Acid → (S)-4-(2-Amino-propan-1-yl)-morpholine

HRID 84735ノート

反応式

HRID 84735 の反応式
C(OC(=O)[NH:7][CH:8]([CH3:16])[CH2:9][N:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1)(C)(C)C.Cl>CO>[CH3:16][C@H:8]([NH2:7])[CH2:9][N:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 15326463(1-Methyl-2-morpholin-4-yl-ethyl)-carbamic acid tert-butyl ester

生成物 1

HCID 7004115(S)-4-(2-Amino-propan-1-yl)-morpholine収率 142.1%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of (1-methyl-2-morpholin-4-yl-ethyl)-carbamic acid tert-butyl ester (0.30 g, 1.22 mmol) in methanol (10 mL) was added 2N HCl (5 mL) at 0° C. The reaction mixture was allowed to warm to room temperature and was stirred overnight. The solvent was removed under vacuum to give (S)-1-Methyl-2-morpholin-4-yl-ethylamine as a light yellow solid (250 mg, 96%). MS (M+H)=145.

後処理

  1. customThe solvent was removed under vacuum

出典と根拠

ORDレコード
ord-32a3f2ff49bc4f9281cdf22028f9da95
出典データセット
uspto-grants-2014_09
特許番号
US08846945B2

反応ノート

読み込み中…