Hydrochloric Acid → FK1052 hydrochloride

HRID 847496ノート

反応式

HRID 847496 の反応式
[CH3:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]2[C:11](=[O:22])[CH:12]([CH2:15][C:16]3[N:17]=[CH:18][NH:19][C:20]=3[CH3:21])[CH2:13][CH2:14][C:3]=12.[ClH:23]>CO.C(O)C>[ClH:23].[CH3:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]2[C:11](=[O:22])[CH:12]([CH2:15][C:16]3[N:17]=[CH:18][NH:19][C:20]=3[CH3:21])[CH2:13][CH2:14][C:3]=12

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 125368FK 1052

生成物 1

HCID 9949384FK1052 hydrochloride

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒2 回HCID 887Methanol溶媒

実験手順

The suspension of 8,9-dihydro-10-methyl-7-[(5-methyl-1H-imidazol-4-yl)methyl]pyrido[1,2-a]indol-6(7H)one (2.0 g) in methanol (60 ml) was treated with hydrogen chloride in ethanol and then diluted with hot aqueous ethanol (water:ethanol, 1:4) to give a clear solution. After filtration of the insoluble materials, the filtrate was evaporated under reduced pressure to about 40 ml and allowed to stand at room temperature overnight. Filtration, followed by washing with ethanol, gave 8,9-dihydro-10-methyl-7-[(5-methyl-1H-imidazol-4-yl)-methyl]pyrido[1,2-a]indol-6(7H)-one hydrochloride (2.10 g) as crystals.

後処理

  1. customto give a clear solution
  2. filtrationAfter filtration of the insoluble materials
  3. customthe filtrate was evaporated under reduced pressure to about 40 ml
  4. filtrationFiltration
  5. washby washing with ethanol

出典と根拠

ORDレコード
ord-df2c7ea46e8c4d0bb15763c7c8c81dfc
出典データセット
uspto-grants-1992_08
特許番号
US05141945

反応ノート

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