Methyl Acrylate → 4-Morpholinepropanoic acid, methyl ester

HRID 847636

反応式

HRID 847636 の反応式
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[C:7]([O:11][CH3:12])(=[O:10])[CH:8]=[CH2:9]>ClCCl>[N:1]1([CH2:9][CH2:8][C:7]([O:11][CH3:12])=[O:10])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

参加物

4

反応物 2

HCID 7294Methyl AcrylateHCID 8083Morpholine

生成物 1

HCID 1013734-Morpholinepropanoic acid, methyl ester収率 99%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of 4.9 ml (56 mmol) of morpholine in 50 ml of dichloromethane was treated dropwise with 5.0 ml (56 mmol) of methyl acrylate. The resulting solution was allowed to stand at ambient temperature for 3 days, after which it was concentrated in vacuo to an oil. Chromatography on silica gel using 0.5% methanol/2% isopropylamine in chloroform provided 9.54 g (99%) of the desired compound as a colorless liquid.

後処理

  1. concentrationafter which it was concentrated in vacuo to an oil

出典と根拠

ORDレコード
ord-8edfa088586d458692cabaee57cf64fa
出典データセット
uspto-grants-1992_08
特許番号
US05142056

関連ノート

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