Potassium Carbonate → 2-Bromo-1-(4-fluoro-3-methylphenyl)ethanone
反応式
[Br:1][CH2:2][C:3]([O:5]C)=O.[F:7][C:8]1[CH:13]=[CH:12][C:11](C2N=C(C3C=CC=CC=3)NC=2)=[CH:10][C:9]=1[CH3:25].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[Br:1][CH2:2][C:3]([C:11]1[CH:12]=[CH:13][C:8]([F:7])=[C:9]([CH3:25])[CH:10]=1)=[O:5]参加物
5
実験手順
0.41 mL methyl bromoacetate was added to 1 g 4-(4-fluoro-3-methyl-phenyl)-2-phenyl-1H-imidazole and 1.66 g potassium carbonate in 10 mL DMF. The reaction was stirred 3 h at RT. Then 0.41 mL methyl bromoacetate was added and the reaction was stirred over night at RT. The reaction mixture was added to ice water and extracted with DCM. The organic layer was dried and evaporated to give 1 g desired product. Rt: 0.94 min (method B), (M+H)+: 325
後処理
- stirringthe reaction was stirred over night at RT
- extractionextracted with DCM
- customThe organic layer was dried
- customevaporated
出典と根拠
- ORDレコード
- ord-49f80cdd3df74785b4c3d86c3f87f02e
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08846948B2
反応ノート
読み込み中…