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Dimethylformamide → HCID 86686620、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | 1-(2-Pyrimidinyl)piperazine | HCID 88747 | — |
| 反応物 | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| 反応物 | (2,4,5-Tribromo-imidazol-1-yl)-acetic acid | HCID 86686618 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | HCID 86686620 | HCID 86686620 | — |
反応手順
7.3 mL 2-piperazin-1-yl-pyrimidine was added to a mixture of 17 g (2,4,5-tribromo-imidazol-1-yl)-acetic acid, 16.6 g TBTU, 7.3 mL TEA and 100 mL DMF. The reaction mixture was stirred for 2 h at RT and subsequently added to water. The precipitate was filtered to give 23 g desired product. Rt: 0.93 (method B), ESI+: 507
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08846948B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-3c9d00cd6745421b9277a10b4b73c6d5 |
| 出典メモ | uspto-grants-2014_09 |