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1-(2-Pyrimidinyl)piperazine → 2-(2,4-Diphenyl-imidazol-1-yl)-1-(4-pyrimidin-2-yl-piperazin-1-yl)-ethanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(2-Pyrimidinyl)piperazine | HCID 88747 | — |
| 反応物 | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| 反応物 | (2,4-Diphenyl-imidazol-1-yl)-acetic acid | HCID 86686623 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-(2,4-Diphenyl-imidazol-1-yl)-1-(4-pyrimidin-2-yl-piperazin-1-yl)-ethanone | HCID 71586582 | 48.4% |
反応手順
40 mg 2-piperazin-1-yl-pyrimidine was added to 70 mg (2,4-diphenyl-imidazol-1-yl)-acetic acid, 80 mg TBTU, 50 μL TEA in 1 mL DMF. The reaction was stirred overnight at RT. The mixture was purified by HPLC to give 50 mg desired product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08846948B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-000f2c008bf444348603f18d2754f9fe |
| 出典メモ | uspto-grants-2014_09 |