HCID 70576832、化合物 → HCID 12939743、化合物
反応式
Br.[NH:2]1[C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[N:4]=[C:3]1[S:11][CH:12]([C:17](=[O:25])[C:18]1[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=1)[CH2:13][C:14]([OH:16])=[O:15]>C([O-])(O)=O.[Na+]>[NH:2]1[C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[N:4]=[C:3]1[S:11][CH:12]([C:17](=[O:25])[C:18]1[CH:19]=[CH:20][C:21]([Cl:24])=[CH:22][CH:23]=1)[CH2:13][C:14]([OH:16])=[O:15]参加物
3
実験手順
30 g of the 3-(imidazo[4,5-b]pyridine-2-ylthio)-3-(4-chlorobenzoyl)propionic acid hydrobromide obtained above are dissolved in a dilute NaHCO3 solution (25 g NaHCO3 in 800 ml water), and the solution is filtered and the filtrate acidified with acetic acid. The solid is collected, washed well with water and air dried, yielding 20 g of material. The solid is recrystallized from hot acetonitrile. The title compound decomposes at about 140° C.
後処理
- filtrationthe solution is filtered
- customThe solid is collected
- washwashed well with water and air