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Methanol → 4-Chloro-2-methoxybenzothiazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 2-Bromo-4-chlorobenzothiazole | HCID 77178 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-Chloro-2-methoxybenzothiazole | HCID 4141969 | 93.8% |
反応手順
2-Bromo-4-chlorobenzothiazole (6.21 g, 0.025 mole) and 94% sodium hydroxide (1.57 g, 0.037 mole) were added to methanol (100 c.c.), and the mixture was heated under reflux for 30 minutes. After cooling, water (100 c.c.) was added to the reaction solution, followed by ice-cooling. The deposited crystals were filtered and washed with water to obtain 4.68 g of 2-methoxy-4-chlorobenzothiazole. Yield 93.8%, purity 99.3%, m.p. 55°-57° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04293702 |
| 出典データセット | uspto-grants-1981_10 |
| ORD ID | ord-6e26b00862f84353ab12bbfba02506a2 |
| 出典メモ | uspto-grants-1981_10 |