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Sodium Hydroxide → 4-Chloro-2-methoxybenzothiazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 2,4-Dichlorobenzothiazole | HCID 77177 | — |
| 反応物 | Methanol--water (1/1) | HCID 22242641 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-Chloro-2-methoxybenzothiazole | HCID 4141969 | 92.4% |
反応手順
2,4-Dichlorobenzothiazole (10.21 g, 0.05 mole) and 94% sodium hydroxide (8.30 g, 0.075 mole) were added to a 50 (V/V) % water/methanol mixed solvent (150 c.c.), and the mixture was heated under reflux for 30 minutes. After cooling, water (100 c.c.) was added to the reaction solution, followed by ice-cooling. The deposited crystals were filtered and washed with water to obtain 9.22 g of 2-methoxy-4-chlorobenzothiazole. Yield 92.4%, purity 100%, m.p. 55°-57° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04293702 |
| 出典データセット | uspto-grants-1981_10 |
| ORD ID | ord-1378ba8683e34588b66f6a2080ac745c |
| 出典メモ | uspto-grants-1981_10 |