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Water → 4-Chloro-2-ethoxy-1,3-benzothiazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 2,4-Dichlorobenzothiazole | HCID 77177 | — |
| 反応物 | 2-Bromo-4-chlorobenzothiazole | HCID 77178 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4-Chloro-2-ethoxy-1,3-benzothiazole | HCID 12766006 | 92.9% |
反応手順
A mixture (20.87 g, 0.1 mole) of 2-bromo-4-chlorobenzothiazole and 2,4-dichlorobenzothiazole and 94% sodium hydroxide (4.68 g, 0.11 mole) in 95% ethanol (200 c.c.) was heated under reflux for 1 hour. After cooling, water (250 c.c.) was added to the reaction solution, followed by ice-cooling. The deposited crystals were filtered and washed with water to obtain 19.86 g of 2-ethoxy-4-chlorobenzothiazole. Yield 92.9%, purity 98.9%, m.p. 43°-45° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04293702 |
| 出典データセット | uspto-grants-1981_10 |
| ORD ID | ord-cc1e255ac7744471b5cc99e783ebf1c7 |
| 出典メモ | uspto-grants-1981_10 |