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Water → 2-n-Propoxy-4-chlorobenzothiazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 2,4-Dichlorobenzothiazole | HCID 77177 | — |
| 反応物 | 2-Bromo-4-chlorobenzothiazole | HCID 77178 | — |
| 溶媒 | 1-Propanol | HCID 1031 | — |
| 生成物 | 2-n-Propoxy-4-chlorobenzothiazole | HCID 12766007 | 97.7% |
反応手順
A mixture (11.30 g, 0.05 mole) of 2-bromo-4-chlorobenzothiazole and 2,4-dichlorobenzothiazole and 94% sodium hydroxide (2.34 g, 0.055 mole) in n-propanol (100 c.c.) was heated under reflux for 1 hour. Water was added and the alcohol was distilled azeotropically together with water. The resulting oily substance was extracted with chloroform, and the chloroform layer was washed with water. The solvent was removed under reduced pressure to obtain 11.12 g of 2-n-propoxy-4-chlorobenzothiazole as a yellow viscous liquid. Yield 97.7%, purity 98.9%, b.p. 106°-108° C./0.12 mmHg.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04293702 |
| 出典データセット | uspto-grants-1981_10 |
| ORD ID | ord-705986d35b744ee8a86accc645a337d5 |
| 出典メモ | uspto-grants-1981_10 |