関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Chloroform | HCID 6212 | — |
| 反応物 | Dimethyl Sulfate | HCID 6497 | — |
| 反応物 | 4-Chloro-2-methoxybenzothiazole | HCID 4141969 | — |
| 生成物 | 4-chloro-N-methylbenzothiazolone | HCID 69645010 | 99.7% |
反応手順
A mixture of 4-chloro-2-methoxybenzothiazole (3.00 g, 0.015 mole) and dimethyl sulfate (95 mg, 7.5×10-4 mole) was heated at 150° C. for 3 hours with stirring. After cooling, the reaction mass was dissolved in chloroform, and the chloroform layer was washed with an aqueous solution saturated with sodium carbonate and then with water. The solvent was removed under reduced pressure to obtain 2.99 g of 4-chloro-N-methylbenzothiazolone as white crystals. Yield 99.7%, purity 99.0%, m.p. 130°-132° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04293702 |
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| 出典データセット | uspto-grants-1981_10 |
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| ORD ID | ord-3430b6b0385643a59c87c7ea15694002 |
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| 出典メモ | uspto-grants-1981_10 |
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