関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Sunitinib hydrochloride | HCID 86691060 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Sunitinib | HCID 5329102 | 78.3% |
反応手順
Sunitinib hydrochloride (1.0 g) and H2O (60 mL) was added into a flask in r.t. and heated to 90° C., the mixture turned clear, pH of the mixture was adjusted to 8˜9 with 1N NaOH and cooled r.t. stirred over night, filtered, washed, dried in vacuo to give 0.67 g of crude sunitinib with 99.0% purity by HPLC analysis in 78.3% yield.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08846953B2 |
|---|
| 出典データセット | uspto-grants-2014_09 |
|---|
| ORD ID | ord-ec7d05eb1cef40c8b6783229183d3fe6 |
|---|
| 出典メモ | uspto-grants-2014_09 |
|---|
