1,3-Propanediamine → N-methyl-N'-[2-(2-(3-isothiazolyl)ethyl)aminoethyl]thiourea

反応式

Br[CH2:2][C:3]1[CH:7]=[CH:6][S:5][N:4]=1.[NH2:8][CH2:9]CCN.[CH3:13][NH:14][C:15]([NH:17][CH2:18][CH2:19]CNCC1C=CSN=1)=[S:16]>>[CH3:13][NH:14][C:15]([NH:17][CH2:18][CH2:19][NH:8][CH2:9][CH2:2][C:3]1[CH:7]=[CH:6][S:5][N:4]=1)=[S:16]

参加物

反応物 3

HCID 4281,3-Propanediamine

HCID 130375983-(bromomethyl)Isothiazole

HCID 20557673N-methyl-N'-[3-(3-isothiazolylmethylamino)propyl]thiourea

生成物 1

HCID 20557666N-methyl-N'-[2-(2-(3-isothiazolyl)ethyl)aminoethyl]thiourea

実験手順

In addition, using in the procedure of Example 40(a), 3-bromomethylisothiazole and 1,3-diaminopropane as the starting materials, the product is N-methyl-N'-[3-(3-isothiazolylmethylamino)propyl]thiourea.

出典と根拠

ORDレコード: ord-2f3f2f95fcb04f93b10efc1114671e15
出典データセット: uspto-grants-1981_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04293697

反応ノート

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