3-Chloro-N,N-dimethyl-1-propanamine → Sulfoximine, N-(3-(dimethylamino)propyl)-S-phenyl-S-2-thienyl-

HRID 848066ノート

反応式

HRID 848066 の反応式
[C:1]1([S:7]([C:10]2[S:11][CH:12]=[CH:13][CH:14]=2)(=[NH:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:15][N:16]([CH3:21])[CH2:17][CH2:18][CH2:19]Cl>>[CH3:15][N:16]([CH3:21])[CH2:17][CH2:18][CH2:19][N:9]=[S:7]([C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)([C:10]1[S:11][CH:12]=[CH:13][CH:14]=1)=[O:8]

参加物

3

反応物 2

HCID 669603-Chloro-N,N-dimethyl-1-propanamineHCID 20566262HCID 20566262、化合物

生成物 1

HCID 3054391Sulfoximine, N-(3-(dimethylamino)propyl)-S-phenyl-S-2-thienyl-収率 38%

実験手順

In a manner analogous to that described in Example 1, Stage 3, by the reaction of phenyl-(2-thienyl)-sulphoximide with 3-dimethylaminopropyl chloride, there is obtained, in a yield of 38% of theory, N-(3-dimethylaminopropyl)-S-phenyl-S-(2-thienyl)-sulphoximide, the fumarate of which, after recrystallisation from ethyl acetate/isopropanol, melts at 125° C.

出典と根拠

ORDレコード
ord-4eda5d77d4434e1e9fcb088356b9abff
出典データセット
uspto-grants-1981_10
特許番号
US04294838

反応ノート

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