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Hydrochloric Acid → 2-Acetoxyethyl chloromethyl sulfide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Formaldehyde | HCID 712 | — |
| 反応物 | Ethanol, 2-mercapto-, 1-acetate | HCID 98505 | — |
| 反応物 | Calcium Chloride | HCID 5284359 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-Acetoxyethyl chloromethyl sulfide | HCID 12899610 | — |
反応手順
Hydrogen chloride gas was introduced into a mixture of 2-acetoxyethanethiol (24.0 g) and paraformaldehyde (6.0 g) at a moderate rate with external cooling for 3 hours. Calcium chloride (25 g) was added and the reaction mixture allowed to stand in a salt-ice bath for 4 hours. Methylene chloride (200 ml) was added, the reaction mixture filtered and the solvent evaporated with rigorous exclusion of moisture. The residual oil was distilled to give 2-acetyloxyethyl chloromethyl sulfide (18.5 g, bp 82°-87° C. at 3 mm Hg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04294831 |
| 出典データセット | uspto-grants-1981_10 |
| ORD ID | ord-fc2246409df24526af69bcb58888db99 |
| 出典メモ | uspto-grants-1981_10 |