HCID 54539058、化合物 → HCID 131712512、化合物
反応式
[CH2:1]([OH:24])[C@@H:2]([OH:23])[C@H:3]([OH:22])[C@H:4]([O:9][C@@H:10]1[O:15][C@H:14]([C:16]([OH:18])=[O:17])[C@@H:13]([OH:19])[C@H:12]([OH:20])[C@H:11]1[OH:21])[C@@H:5]([NH2:8])[CH:6]=[O:7].BrCC([C@H:29]1[CH2:46][CH2:45][C@@:44]2([CH3:47])[C:31](=[CH:32][CH2:33][C@@H:34]3[C@@H:43]2[CH2:42][CH2:41][C@@:39]2([CH3:40])[C@H:35]3[CH2:36][CH2:37][C:38]2=[O:48])[CH2:30]1)=O>CS(C)=O.[Ag]>[CH2:1]([OH:24])[C@@H:2]([OH:23])[C@H:3]([OH:22])[C@H:4]([O:9][C@@H:10]1[O:15][C@H:14]([C:16]([OH:18])=[O:17])[C@@H:13]([OH:19])[C@H:12]([OH:20])[C@H:11]1[OH:21])[C@@H:5]([NH2:8])[CH:6]=[O:7].[CH3:40][C@@:39]12[C:38](=[O:48])[CH2:37][CH2:36][C@H:35]1[C@@H:34]1[CH2:33][CH:32]=[C:31]3[CH2:30][C@@H:29]([OH:7])[CH2:46][CH2:45][C@:44]3([CH3:47])[C@H:43]1[CH2:42][CH2:41]2参加物
5
実験手順
1.133 Grams (0.00245 mole) of silver salt of chondrosine was dissolved in 70 ml of DMSO (dimethylsulfoxide) and 0.84 g of the compound (1) was added to the solution to react them at room temperature for 2 days. After the reaction, AgBr was separated by a centrifugal separation and DMSO was distilled off from the resulting supernatant at 45° to 50° C. under a reduced pressure and then, 70 ml of ethanol was added to the residual solid and a floating insoluble material was separated and a filtrate was concentrated under a reduced pressure and poured into 2 ml of cold water to precipitate the product. The precipitate was dried and washed with ether and dried to obtain 0.36 g of a conjugate of chondrosine-dehydroepiandrosterone having the formula ##STR1##