Dimethyl Sulfoxide → HCID 12774893、化合物

HRID 848637ノート

反応式

HRID 848637 の反応式
Cl[CH:2]1[CH2:6][CH2:5][O:4][CH:3]1[N:7]1[C:12](=[O:13])[NH:11][C:10](=[O:14])[CH:9]=[N:8]1.CC(C)([O-])C.[K+].CS(C)=O>C(O)(=O)C>[O:4]1[CH2:5][CH:6]=[CH:2][CH:3]1[N:7]1[C:12](=[O:13])[NH:11][C:10](=[O:14])[CH:9]=[N:8]1

参加物

5

反応物 3

HCID 679Dimethyl SulfoxideHCID 127749012-(3-Chlorooxolan-2-yl)-1,2,4-triazine-3,5(2H,4H)-dioneHCID 23665647Potassium tert-butoxide

生成物 1

HCID 12774893HCID 12774893、化合物

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

2-(3-Chloro-tetrahydro-2-furanyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine (0.8 g) and potassium t-butoxide (0.7 g) are added to dimethyl sulfoxide (3 ml), and the mixture is stirred at room temperature for 3 hours. The reaction mixture is poured into ice-water. The mixture is acidified with acetic acid and extracted with chloroform. The chloroform extract is washed with water, dried and evaporated to remove the solvent. The crude residue is recrystallized from ethanol to give 2-(2,5-dihydro-2-furanyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine (Compound No. 81). Yield, 0.5 g (76%). M.P., 147°-148° C.

後処理

  1. extractionextracted with chloroform
  2. extractionThe chloroform extract
  3. washis washed with water
  4. customdried
  5. customevaporated
  6. customto remove the solvent
  7. customThe crude residue is recrystallized from ethanol

出典と根拠

ORDレコード
ord-aed1f257c4e94e90b2af6397342a3b5f
出典データセット
uspto-grants-1981_10
特許番号
US04297129

反応ノート

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