Hydrochloric Acid → 2-(3-carbamoylphenylamino)-N-(3,4-dimethoxyphenethyl)acetamide trihydrate

HRID 848732ノート

反応式

HRID 848732 の反応式
Cl.[C:2]([C:5]1[CH:6]=[C:7]([NH:11][CH2:12][C:13]([NH:15][CH2:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[C:20]([O:26][CH3:27])[CH:19]=2)=[O:14])[CH:8]=[CH:9][CH:10]=1)(=[O:4])[NH2:3].Cl>O>[OH2:4].[OH2:4].[OH2:4].[C:2]([C:5]1[CH:6]=[C:7]([NH:11][CH2:12][C:13]([NH:15][CH2:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[C:20]([O:26][CH3:27])[CH:19]=2)=[O:14])[CH:8]=[CH:9][CH:10]=1)(=[O:4])[NH2:3]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 156650Benzamide, 3-((2-((2-(3,4-dimethoxyphenyl)ethyl)amino)-2-oxoethyl)amino)-, monohydrochloride

生成物 1

HCID 221497912-(3-carbamoylphenylamino)-N-(3,4-dimethoxyphenethyl)acetamide trihydrate収率 321.6%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To 5.0 g of 2-(3-carbamoylphenylamino)-N-(3,4-dimethoxyphenethyl)acetamide hydrochloride was added 500 ml of water heated at 55° to 60° C. and the mixture was stirred while heating at the same temperature until the hydrochloride completely dissolved. After allowing the mixture to stand overnight, the crystals precipitated were collected by filtration, washed with water and air-dried by allowing to stand at room temperature for 10 days to obtain 4.2 g of 2-(3-carbamoylphenylamino)-N-(3,4-dimethoxyphenethyl)acetamide trihydrate as colorless needles having a melting point of 53.5°-55.5° C.

後処理

  1. temperatureheated at 55° to 60° C.
  2. dissolutioncompletely dissolved
  3. customthe crystals precipitated
  4. filtrationwere collected by filtration
  5. washwashed with water
  6. customair-dried
  7. waitto stand at room temperature for 10 days

出典と根拠

ORDレコード
ord-13cae5ef6f70425ca242cc5392d03172
出典データセット
uspto-grants-1981_10
特許番号
US04297357

反応ノート

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