3-[[2-[2-(3,4-Dimethoxyphenyl)ethylamino]-2-oxoethyl]amino]benzamide → 2-(3-carbamoylphenylamino)-N-(3,4-dimethoxyphenethyl)acetamide trihydrate

HRID 848735ノート

反応式

HRID 848735 の反応式
[C:1]([C:4]1[CH:5]=[C:6]([NH:10][CH2:11][C:12]([NH:14][CH2:15][CH2:16][C:17]2[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[C:19]([O:25][CH3:26])[CH:18]=2)=[O:13])[CH:7]=[CH:8][CH:9]=1)(=[O:3])[NH2:2]>O>[OH2:3].[OH2:3].[OH2:3].[C:1]([C:4]1[CH:5]=[C:6]([NH:10][CH2:11][C:12]([NH:14][CH2:15][CH2:16][C:17]2[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[C:19]([O:25][CH3:26])[CH:18]=2)=[O:13])[CH:7]=[CH:8][CH:9]=1)(=[O:3])[NH2:2]

参加物

3

反応物 1

HCID 1566513-[[2-[2-(3,4-Dimethoxyphenyl)ethylamino]-2-oxoethyl]amino]benzamide

生成物 1

HCID 221497912-(3-carbamoylphenylamino)-N-(3,4-dimethoxyphenethyl)acetamide trihydrate収率 225.8%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To 0.2 g of pulverized 2-(3-carbamoylphenylamino)-N-(3,4-dimethoxyphenethyl)acetamide was added 100 ml of water and the mixture was stirred at 60° to 65° C. for 30 minutes to dissolve the powder completely. The solution was then concentrated under reduced pressure at 60° C. until about 40 ml of residual liquid was left, and allowed to stand at room temperature overnight. The colorless needles precipitated were collected by filtration, washed with water and then air-dried by allowing to stand at room temperature to obtain 0.13 g of 2-(3-carbamoylphenylamino)-N-(3,4-dimethoxyphenethyl)acetamide trihydrate having a melting point of 54°-57° C.

後処理

  1. dissolutionto dissolve the powder completely
  2. concentrationThe solution was then concentrated under reduced pressure at 60° C. until about 40 ml of residual liquid
  3. waitwas left
  4. waitto stand at room temperature overnight
  5. customThe colorless needles precipitated
  6. filtrationwere collected by filtration
  7. washwashed with water
  8. customair-dried
  9. customto stand at room temperature

出典と根拠

ORDレコード
ord-f584edcc0fe4495a936c2f46d3771082
出典データセット
uspto-grants-1981_10
特許番号
US04297357

反応ノート

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