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Methanesulfonic Acid → 7-cyano-(1H,3H,5H)-(1)-benzopyrano-(2,3-d)-pyrimidine-4-one-2-thione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanesulfonic Acid | HCID 6395 | — |
| 反応物 | Thiobarbituric acid | HCID 2723628 | — |
| 反応物 | 3-Formyl-4-hydroxybenzonitrile | HCID 11789350 | — |
| 溶媒 | 1-Butanol | HCID 263 | — |
| 生成物 | 7-cyano-(1H,3H,5H)-(1)-benzopyrano-(2,3-d)-pyrimidine-4-one-2-thione | HCID 12773948 | — |
反応手順
To n-butanol (100 ml.) add 5-cyano-salicylaldehyde (6 g.), 2-thiobarbituric acid (6 g.) and methanesulfonic acid (10 ml.) With stirring, heat the mixture to reflux for 11/2 hours. Cool, filter, and wash the solid with isopropanol and ether to yield 7-cyano-(1H,3H,5H)-(1)-benzopyrano-(2,3-d)-pyrimidine-4-one-2-thione.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04297355 |
| 出典データセット | uspto-grants-1981_10 |
| ORD ID | ord-6443daa7b40a4185803feb655054d997 |
| 出典メモ | uspto-grants-1981_10 |