Hydrochloric Acid → (R)-2-amino-3-(pyridin-2-yl)propanamide hydrochloride

HRID 84881ノート

反応式

HRID 84881 の反応式
[NH2:1][C:2](=[O:19])[C@H:3]([NH:11]C(=O)OC(C)(C)C)[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][N:6]=1.[ClH:20]>>[ClH:20].[NH2:11][C@H:3]([CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][N:6]=1)[C:2]([NH2:1])=[O:19]

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 67774698(R)-tert-butyl 1-amino-1-oxo-3-(pyridin-2-yl)propan-2-ylcarbamate

生成物 1

HCID 67508637(R)-2-amino-3-(pyridin-2-yl)propanamide hydrochloride

実験手順

A solution of (R)-tert-butyl 1-amino-1-oxo-3-(pyridin-2-yl)propan-2-ylcarbamate (280 mg, 0.739 mmol) in aq. 6N HCl (8 mL) was stirred at room temperature for 2 h. It was then concentrated in vacuo to give (R)-2-amino-3-(pyridin-2-yl)propanamide hydrochloride (170 mg).

後処理

  1. concentrationIt was then concentrated in vacuo

出典と根拠

ORDレコード
ord-beec39d9180e4d63b74b5c63d5450de0
出典データセット
uspto-grants-2014_09
特許番号
US08846928B2

反応ノート

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