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6-Benzylpyridin-2-amine → HCID 178507544、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 6-Benzylpyridin-2-amine | HCID 93902 | — |
| 触媒 | Rhodium | HCID 23948 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | HCID 178507544 | HCID 178507544 | — |
反応手順
Example 298) A sample of the 2-amino-6-benzylpyridine product of Example 298 A was reduced in acetic acid under hydrogen atmosphere utilizing 5% Rh/C catalyst to afford 2-imino-6-benzylpiperidine as an oil. The oil was purified by C-18 reverse phase chromatography to give a white solid. The solid was dissolved in 1N HCl, lyophilized, and recrystallized from EtOH/EtOAc to give the title product as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06011028 |
| 出典データセット | uspto-grants-2000_01 |
| ORD ID | ord-f969f49f24934845b7a38b501b51d7de |
| 出典メモ | uspto-grants-2000_01 |