(R)-7-cyano-2,3,4,5-tetrahydro-4-(phenylacetyl)-3-(phenylmethyl)-1H-1,4-benzodiazepine → 7-Bromo-2,3,4,5-tetrahydro-3-(hydroxymethyl)-1-(1H-imidazol-4-ylmethyl)-4-(methylsulfonyl)-1 H-1,4-benzodiazepine, monohydrochloride
反応式
C(C1C=CC2NC[C@@H](CC3C=CC=CC=3)N(C(=[O:28])CC3C=CC=CC=3)CC=2C=1)#N.[ClH:30].[Br:31][C:32]1[CH:33]=[CH:34][C:35]2[N:41]([CH2:42][C:43]3[N:44]=[CH:45][NH:46][CH:47]=3)[CH2:40][C@@H:39]([CH2:48]C3C=CC=CC=3)[N:38]([S:55]([CH3:58])(=[O:57])=[O:56])[CH2:37][C:36]=2[CH:59]=1>>[ClH:30].[Br:31][C:32]1[CH:33]=[CH:34][C:35]2[N:41]([CH2:42][C:43]3[N:44]=[CH:45][NH:46][CH:47]=3)[CH2:40][CH:39]([CH2:48][OH:28])[N:38]([S:55]([CH3:58])(=[O:57])=[O:56])[CH2:37][C:36]=2[CH:59]=1参加物
3
反応物 2
生成物 1
実験手順
Example 306 was prepared as an offwhite solid in 12% yield from Compound C of Example 305 as described for Compound D of Example 224.
出典と根拠
- ORDレコード
- ord-cc0f531f74144ad99c25faa1ed4d7696
- 出典データセット
- uspto-grants-2000_01
- 特許番号
- US06011029
反応ノート
読み込み中…