Water → 4-Amino-pyrido[2,3-e]pyrimidin-2-one

HRID 849457

反応式

HRID 849457 の反応式
[NH2:1][C:2]1[C:3]([C:8]#[N:9])=[N:4][CH:5]=[CH:6][CH:7]=1.[NH2:10][C:11](N)=[O:12].O>C(OCCOCCO)C>[NH2:9][C:8]1[C:3]2[N:4]=[CH:5][CH:6]=[CH:7][C:2]=2[NH:1][C:11](=[O:12])[N:10]=1

参加物

5

反応物 3

HCID 962WaterHCID 1176UreaHCID 5770153-Aminopyridine-2-carbonitrile

生成物 1

HCID 193668794-Amino-pyrido[2,3-e]pyrimidin-2-one

試薬・触媒・溶媒 1

HCID 8146Diethylene Glycol Monoethyl Ether溶媒

反応条件

温度
205 °C

実験手順

A slurry of 3-Amino-2-cyanopyridine (200 mg) and urea (400 mg) in 2-(2-ethoxyethoxy)ethanol (0.5 mL) was gradually heated to about 205° C., and maintained at 205° C. for 10 min. Heating was ceased and 6 mL of hot water was carefully added while shaking the mixture. The mixture was vacuum filtered to collect the precipitate. The precipitate was washed with water and ethyl acetate and allowed to dry to yield 4-Amino-pyrido[2,3-e]pyrimidin-2-one as a light yellow solid, m.p. >300° C.

後処理

  1. temperatureHeating
  2. filtrationfiltered
  3. customto collect the precipitate
  4. washThe precipitate was washed with water and ethyl acetate
  5. customto dry

出典と根拠

ORDレコード
ord-7ee97355e5a946ffa77f9f3ae2b004a8
出典データセット
uspto-grants-2000_01
特許番号
US06013650

関連ノート

読み込み中…