Water → 4-Amino-pyrido[2,3-e]pyrimidin-2-one
反応式
[NH2:1][C:2]1[C:3]([C:8]#[N:9])=[N:4][CH:5]=[CH:6][CH:7]=1.[NH2:10][C:11](N)=[O:12].O>C(OCCOCCO)C>[NH2:9][C:8]1[C:3]2[N:4]=[CH:5][CH:6]=[CH:7][C:2]=2[NH:1][C:11](=[O:12])[N:10]=1参加物
5
反応条件
- 温度
- 205 °C
実験手順
A slurry of 3-Amino-2-cyanopyridine (200 mg) and urea (400 mg) in 2-(2-ethoxyethoxy)ethanol (0.5 mL) was gradually heated to about 205° C., and maintained at 205° C. for 10 min. Heating was ceased and 6 mL of hot water was carefully added while shaking the mixture. The mixture was vacuum filtered to collect the precipitate. The precipitate was washed with water and ethyl acetate and allowed to dry to yield 4-Amino-pyrido[2,3-e]pyrimidin-2-one as a light yellow solid, m.p. >300° C.
後処理
- temperatureHeating
- filtrationfiltered
- customto collect the precipitate
- washThe precipitate was washed with water and ethyl acetate
- customto dry
出典と根拠
- ORDレコード
- ord-7ee97355e5a946ffa77f9f3ae2b004a8
- 出典データセット
- uspto-grants-2000_01
- 特許番号
- US06013650
反応ノート
読み込み中…