関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Phenacyl bromide | HCID 6259 | — |
| 反応物 | 4-Amino-pyrido[2,3-e]pyrimidin-2-one | HCID 19366879 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | HCID 135418313 | HCID 135418313 | — |
反応手順
A mixture of 4-Amino-pyrido[2,3-e]pyrimidin-2-one (95 mg) and α-bromo-acetophenone (117 mg) in 4 mL of dimethylformamide (DMF) was heated at about 150° C. for 20 min. The reaction mixture was concentrated in vacuo and the residue was subjected to flash chromatography on silica gel with 10% methanol/methylene chloride as the eluent to afford 2-Phenyl-imidazo[1,2-c]pyrido[2,3-e]pyrimidin-5(6H)-one. (Compound 15), m.p. 329-330° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06013650 |
|---|
| 出典データセット | uspto-grants-2000_01 |
|---|
| ORD ID | ord-22c01a3dc17a4e2bb43d97b25f1f605e |
|---|
| 出典メモ | uspto-grants-2000_01 |
|---|
